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Henry N. Ginsberg

Herbert and Florence Irving Professor of Medicine; Director, Irving Institute for Clinical and Translational Research
Department: 
Medicine, Department of
Office: 
PH Room 10-305 622 West 168th St
Email: 
hng1@columbia.edu
Phone: 
212-305-9562
Fax: 
212-305-3213
Biography

Dr. Ginsberg conducts research related to the regulation of the levels and metabolism of apolipoprotein B-containing lipoproteins, the lipoproteins carrying triglycerides and the bulk of cholesterol in blood. These include the atherogenic very low density and low density lipoproteins. Dr. Ginsberg has a particular emphasis on the pathophysiology of hypertriglyceridemia and the dyslipidemia associated with insulin resistance and diabetes mellitus. Research is conducted at three levels: tissue culture using both human and rat hepatoma cells, transgenic mice, and human clinical studies. In cultured cells, Dr. Ginsberg and his associates have described the role of lipid substrate availability in determining if newly synthesized a of degradation and lipoprotein assembly of apoB. His group has characterized the role of the proteasome in the degradation of apoB. 

In transgenic mice, he had developed a model of insulin resistance and dylipidemia with many characteristics of the human disorder. This model, as well as others now in use in the lab, allow the group to dissect the important components of substrate availability and genetic control that lead to hypertriglyceridemia. Dr. Ginsberg’s group makes and studies transgenic mice, conducting whole body, cellular, and molecular experiments. 

In clinical studies, Dr. Ginsberg is investigating postprandial hyperlipidemia as a risk factor in patients with diabetes. He is also part of a group at Columbia that will be studying the role of glycemic, lipid and blood pressure control in the prevention of cardiovascular disease in patients with diabetes. The latter, named the ACCORD trial, is a 10-year trial with 10,000 patients at 6 sites across the United States. Dr. Ginsberg also has a long record of research into the effects of diet on lipid and lipoprotein metabolism in humans, and has conducted numerous controlled feeding studies in humans.

Research & Other Works
Article
An Automated Approach to Map Winter Cropped Area of Smallholder Farms across Large Scales Using MODIS Imagery
Article
Estimates of fire emissions from an active deforestation region in the southern Amazon based on satellite data and biogeochemical modelling
Article
Land-use dynamics influence estimates of carbon sequestration potential in tropical second-growth forest
Data from: Fragmentation increases wind disturbance impacts on forest structure and carbon stocks in a Western Amazonian landscape
Article
Is voluntary certification of tropical agricultural commodities achieving sustainability goals for small-scale producers? A review of the evidence
Article
Factors associated with long-term species composition in dry tropical forests of Central India
Article
Effectiveness of Roundtable on Sustainable Palm Oil (RSPO) for reducing fires on oil palm concessions in Indonesia from 2012 to 2015
Article
Regional air quality impacts of future fire emissions in Sumatra and Kalimantan
Article
Public health impacts of the severe haze in Equatorial Asia in September-October 2015: demonstration of a new framework for informing fire management strategies to reduce downwind smoke exposure
Article
Fire emissions and regional air quality impacts from fires in oil palm, timber, and logging concessions in Indonesia
Article
Mapping Species Composition of Forests and Tree Plantations in Northeastern Costa Rica with an Integration of Hyperspectral and Multitemporal Landsat Imagery
Article
Anthropogenic Drivers of Ecosystem Change: an Overview
Article
Biophysical and Socioeconomic Factors Associated with Forest Transitions at Multiple Spatial and Temporal Scales
Article
High-yield oil palm expansion spares land at the expense of forests in the Peruvian Amazon
Article
Land cover change interacts with drought severity to change fire regimes in Western Amazonia
Article
Sensitivity of crop cover to climate variability: Insights from two Indian agro-ecoregions
Article
Winter crop sensitivity to inter-annual climate variability in central India
Article
Mapping cropping intensity of smallholder farms: A comparison of methods using multiple sensors
Article
El Niño and health risks from landscape fire emissions in southeast Asia
Article
North Tropical Atlantic influence on western Amazon fire season variability
 
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