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David Jonathan Brenner

Higgins Professor of Radiation Biophysics (in Radiation Oncology) and of Environmental Health Sciences; Director, Center for Radiological Research
Public Health
Environmental Health Sciences, Radiation Oncology Department
630 West 168th Street New York, NY 10032
212 305-3229
  • Director, Radiological Research Accelerator Facility

Dr. Brenner focuses on developing mechanistic models for the effects of ionizing radiation on living systems, both at the chromosomal and the animal (or human) levels. He divides his research time roughly equally between the effects of high doses of ionizing radiation (relating to radiation therapy) and the effects of low doses of radiation (relating to medical, environmental and occupational exposures).

At the chromosomal level, he has focused on the mechanisms of radiation-induced chromosome aberrations, and the potential of chromosome aberrations for use as biomarkers for past exposure to different types of radiations.

In the field of medical imaging, he has focused on the risk / benefit balance of the higher-dose imaging techniques, particularly computed tomography (CT).

In the field of radiotherapy, he has focused on optimizing fractionation schemes for different tumor types, to maximize tumor killing and minimize serious side effects; this includes modeling the mechanisms of radiotherapy-induced second cancers, with the goal of reducing second cancer risks.

Environmentally, he has focused on the biological effects of radon, both at the chromosomal and the human levels.

Research & Other Works
CT Pulmonary Angiography: Increasingly Diagnosing Less Severe Pulmonary Emboli
Potential Reduction of Contralateral Second Breast-Cancer Risks by Prophylactic Mammary Irradiation: Validation in a Breast-Cancer-Prone Mouse Model
207-nm UV Light—A Promising Tool for Safe Low-Cost Reduction of Surgical Site Infections. II: In-Vivo Safety Studies
High Throughput Measurement of γH2AX DSB Repair Kinetics in a Healthy Human Population
γ-H2AX Kinetic Profile in Mouse Lymphocytes Exposed to the Internal Emitters Cesium-137 and Strontium-90
Mechanism of Radiation-Induced Bystander Effects: A Unifying Model
Mechanism of Radiation-Induced Bystander Effect: Role of the Cyclooxygenase-2 Signaling Pathway
A comparison of mantle versus involved-field radiotherapy for Hodgkin's lymphoma: reduction in normal tissue dose and second cancer risk
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